By Linda A. Felton, James W. McGinity
This hugely praised booklet provides an in-depth research of actual and chemical homes and functions of aqueous-based polymeric coatings-covering lined dosage varieties, movie defects, and polymer characterization. New chapters on plastisizers and their purposes in pharmaceutical coatings, adhesion of polymeric movies to stable substrates, and the impact of pigments on homes of the polymeric coating structures are integrated during this 3rd version. also, this identify offers new fabric on polymer interactions with medicines and excipients and actual getting older of polymeric movies.
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Extra info for Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences)
Brown derived the capillary pressure, PC, for the sphere of radius R, between three contiguous latex particles (Fig. 9γw /r where γw = polymer–water interfacial tension. Whether attributed to dry sintering or capillary pressure, both mechanisms share the same pseudolatex particle size dependency. The smaller the particle size, the greater the driving force for coalescence, as shown in Figure 9 (9). Various authors have further refined the Brown equation, as reviewed by Steward (10) in his thesis.
Using hydrophobic polymers, the dry MFFT was virtually identical to the wet MFFT, indicating that capillary forces contributed little to film formation. However, the author was unable to rule out that capillary forces may have an effect in more hydrophilic systems. Plasticization by water was said to be the cause of hydrophilic polymers yielding wet MFFTs, which were lower than the dry MFFTs by up to 10°C. Lissant (13) postulated that closely packed spheres above the maximum packing volume (74%, face-centered cubic configuration) will deform at a constant volume to fill all of the space, forming a rhomboid dodecahedron.
If the polymer Tg is Figure 16 Effect of sufficient/insufficient plasticizer content on coating morphology. Abbreviation: DBS, dibutyl sebacate. 18 Carlin et al. 8 at 170°C Insoluble NA Nonvolatile Negligible Abbreviations: DBS, dibutyl sebacate; DEP, diethyl phthalate; TEC, triethyl citrate; TBC, tributyl citrate; ATBC, acetyl tributyl citrate. higher than the desired operating temperatures for coating, it is necessary to add a plasticizer to the dispersion to obtain good film formation. , transparent and crack free) also depends on the MFFT of the polymer film, which in turn depends on the elastic modulus (resistance to particle deformation).