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By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)

The challenge of senescence, as mirrored within the background of reli­ gion and philosophy, has lengthy been one of many maximum issues of humankind. against this, gerontology as a department of technological know-how remains to be relatively younger. prior to now decade, concomitant with quick development in our figuring out of the fundamental lifestyles sciences, significant shops of data approximately organic getting older were amassed. this information, even though, coming up from many medical disciplines and occupied with various degrees of biologic association, turns out virtually random and covers every little thing from molecules to human societies. Theories complex to interpret the evidence and to appreciate the mech­ anisms interested in senescence have remained in person, instead of common, territories. It has lengthy been felt through a few gerontologists that it was once time for a few of the experts to step again and take a generalist view of gerontology, to reassess and reevaluate the culmination in their analyt­ ical goals at various degrees inside of a broader context. a few others might imagine it nonetheless untimely. It appeared, besides the fact that, that most of these who collected in Tokyo at the get together of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be won in trying to find interrelationships one of the evidence and theories originated within the varied degrees of investiga­ tion in an try to realize and savour the organic drama of senescence as an entity.

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Matsuoka, The relation of cell nuclei and surface membranes to the capacity of cell proliferation in human diploid fibroblasts, in:"Proceedings of XIth International Congress of Gerontology;" Excepta Medica, The Netherlands, p. 149, 1919 •• 12. S. Aizawa, Y. Mitsui, and F. Kurimoto, Cell surface changes accompanying aging in human diploid fibroblasts. II. ~. , in press. 13. H. Sakagomi, Y. Mitsui, S. Murota, and Y. Yamada, Two dimensional electrophoretic analysis of nuclear acidic proteins in senescent human fibroblasts, Cell Struc.

MATSUMURA 37 in culture. Possibilities were that the period of observation was too short to detect polyploid cells, that polyploidizing cells were removed from a culture by outside influences such as trypsinization, or that there were mechanisms preventing a cell from spiralling further. Previously reported observations of cultured rat liver cells support the present model. Richman et ale (15) found that a primary culture of rat hepatocytes containing many binucleated cells did not proliferate, but was able to synthesize DNA upon a hormonal stimulation.

HYDRODYNAMIC PROPERTIES OF COLLAGEN FIBRIL AND AGING Toshiharu Matsumura Department of Cancer Cell Research Institute of Medical Science University of Tokyo Shirokanedai, Minato-ku, Tokyo 108 Japan INTRODUCTION One biochemical approach to aging research has been to isolate bodily structural components, study their physiochemical properties, and establish the molecular basis for bodily changes during the aging process. This approach has been particularly fruitful in the field of connective tissue research, ever since soluble collagen was first isolated from tendon, and synthetic fibrils were reconstituted from the soluble collagen in yitro (1).

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